The Huskers had covered 58 yards on four plays before disaster struck.
Nebraska was threatening to score on its opening drive, but Tanner Lee's fourth pick-six of the season killed what seemed like a promising start.
Lee threw a swing pass to Devine Ozigbo, but the throw was a little bit off-target and bounced into the air off Ozigbo's hands. Wisconsin's Chris Orr picked it off and returned it 78 yards for the touchdown.
Check out a video of the bizarre play below.
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